squamous cell carcinoma of the mouth
Jump to navigation
Jump to search
Introduction
see oral cancer
Etiology
- tobacco, including chewing tobacco
- alcohol further increases risk
- human papilloma virus (HPV)
Epidemiology
- most common type of oral cancer
Pathology
- histopathology (see ref[1] for image)
- hyperchromic, pleomorphic cells with a keratin pearl in connective tissue, case report[1]
Clinical manifestations
- non-healing papule, erosion or ulceration in the mouth
- may be painful
- cervical lymphadenopathy
* see ref[1] for image
Laboratory
Radiology
* evaluate for metastases
Differential diagnosis
- oral hairy leukoplakia
- caused by EBV generally in patients with HIV1 infection
- white, corrugated, hairy looking area on side of tongue
- oral lichen planus
- Behcet disease
- generally manifests in patients in their 20s
- recurrent oral ulcers may last 3 weeks, not 2 months
- secondary syphilis:
- whitish, wart-like lesions (condyloma latum) on mucous membranes
- resolution in 3-6 weeks
Management
- surgical resection
- segmental mandibulectomy*
- selective neck dissection*
* case report[1]
More general terms
More specific terms
Additional terms
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Chaubal TV, Bapat RA Squamous-Cell Carcinoma of the Mouth N Engl J Med 2017; 377:1188. September 21, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28930502 Free full text <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1701886
- ↑ 2.0 2.1 2.2 2.3 NEJM Knowledge+ Gastroenterology
- ↑ Lambert R, Sauvaget C, de Camargo Cancela M, Sankaranarayanan R. Epidemiology of cancer from the oral cavity and oropharynx. Eur J Gastroenterol Hepatol. 2011 Aug;23(8):633-41. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21654320 Review.
- ↑ Ramqvist T, Dalianis T. An epidemic of oropharyngeal squamous cell carcinoma (OSCC) due to human papillomavirus (HPV) infection and aspects of treatment and prevention. Anticancer Res. 2011 May;31(5):1515-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21617204 Review.