secondary syphilis
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Introduction
see syphilis
Etiology
- unprotected intercourse with individual infected with syphilis
- failure to recognize or to treat primary syphilis
Pathology
- infection with Treponema pallidum (syphilis)
- elongation of rete ridges, interface dermatitis, endothelial edema, lymphocytic & plasma cell infiltrate
- immunostaining may reveal Treponema pallidum within the lower 1/3 of the epidermis
Clinical manifestations
- fever
- generalized weakness
- diffuse rash affecting the trunk & palms of hands & soles of feet
- maculopapular, hyperpigmented, & scaly eruption on palms, soles & trunk[1]
- hypopigmented plaques on genitals[1]
- papulosquamous lesions on the trunk[2]
- copper-colored papules on the palms & soles with peripheral adherent scale[2]
Laboratory
- fluorescent treponemal antibody absorption test is reactive
- elevated titer of rapid plasma reagin test
- HIV1 RNA
Management
- intramuscular penicillin G benzathine
More general terms
References
- ↑ 1.0 1.1 1.2 1.3 Bhugra P, Maiti A. Images in Clinical Medicine: Secondary Syphilis. N Engl J Med 2020; 383:1375. Oct 1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32997911 https://www.nejm.org/doi/full/10.1056/NEJMicm2001103
- ↑ 2.0 2.1 2.2 2.3 Elkston CA, Elkston DM Bacterial Skin Infections: More Than Skin Deep. Medscape. July 19, 2021 https://reference.medscape.com/slideshow/infect-skin-6003449
- ↑ 3.0 3.1 Weng PC, Li SH Biett Sign as an Indicator of Secondary Syphilis. Mayo Clinic Proceedings, 2024 Oct 99(10):1545-1546 PMID: https://www.ncbi.nlm.nih.gov/pubmed/39254624 https://www.mayoclinicproceedings.org/article/S0025-6196(24)00219-2/fulltext
- ↑ 4.0 4.1 Zheng Y, Xu M Biett's sign in secondary syphilis QJM. 2023. Aug 26 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37632786 https://academic.oup.com/qjmed/article/117/1/55/7252254