TBC1 domain family member 3L (TBC1D3L)

Function

• acts as a GTPase activating protein for RAB5
• does not act on RAB4 or RAB11 (putative)
• ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation
• palmitoylation is required for membrane localization & protects TBC1D3 from ubiquitination

Structure

• contains 1 Rab-GAP TBC domain

Compartment

• cell membrane, lipid-anchor
• associated with lipid rafts

Genetics

• TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog
• some human genomes encode > 50 copies depending on ethnic origin of the donor

More general terms

• rab GTPase-activating protein (rab-GAP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=101060
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:101060
• UniProt: http://www.uniprot.org/uniprot/B9A6J9.html