TBC1 domain family member 3; prostate cancer gene 17 protein; protein TRE17-alpha; Rab GTPase-activating protein PRC17 (TBC1D3, PRC17, TBC1D3A)

Function

• acts as a GTPase activating protein for RAB5
• does not act on RAB4 or RAB11

Structure

contains 1 Rab-GAP TBC domain

Expression

• expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine & peripheral blood leukocytes

Pathology

• overexpressed in prostate cancers

More general terms

• TBC1 domain family member

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=414059
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=729873
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:414059
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:729873
• OMIM: https://mirror.omim.org/entry/607741
• UniProt: http://www.uniprot.org/uniprot/Q8IZP1.html