cell cycle & apoptosis regulator protein 2; cell division cycle & apoptosis regulator protein 2; DBIRD complex subunit KIAA1967; deleted in breast cancer gene 1 protein; DBC-1; DBC.1; p30 DBC (CCAR2, DBC1, KIAA1967)

Function

• core component of the DBIRD complex
• inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation & p53-mediated apoptosis
• inhibits SUV39H1 methyltransferase activity
• component of a histone H3-specific methyltransferase complex
  • may mediate ligand-dependent transcriptional activation by nuclear hormone receptors
• role in maintaining genomic stability & cellular integrity following UV-induced genotoxic stress
• interacts with ZNF326/ZIRD (direct)
• interacts (via N-terminus) with SIRT1
• interacts (via N-terminus) with SUV39H1
  • interaction abolishes the interaction with SIRT1

Compartment

• nucleus
• recruited to chromatin, post- UV irradiation

Alternative splicing

named isoforms=2

Expression

• expressed ubiquitously in normal tissues

Pathology

• expressed in 84-100% of breast cancer, lung cancer, colon cancer

More general terms

• nuclear protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/607359
• UniProt: http://www.uniprot.org/uniprot/Q8N163.html