acneiform eruption

Etiology

• adverse drug reaction
  • EGF receptor inhibitors
    • cetuximab, sorafenib
  • glucocorticoids
  • anabolic steroids (testosterone), azathioprine, bromides, cyclosporine, disulfiram, iodides, isoniazid, lithium, phenobarbital, phenytoin, progesterone, quinidine, vitamins (thiamine, riboflavin, pyridoxine, vitamin B12 & vitamin D2)
• infections
• hormonal or metabolic disturbance
• genetic diseases

Clinical manifestations

• sudden onset weeks to months after starting medication
• monotonous lesion morphology
• dermatoses that resemble acne vulgaris
• lesions may be papulopustular, nodular, or cystic
• no comedones
• lesions may appear on upper trunk & arms when cause is systemic Differential diagnsis:
• acne vulgaris
• allergic contact dermatitis
• folliculitis
• drug eruption
• eruptive vellus hair cysts
• Favre-Racouchot syndrome (nodular elastosis with cysts & comedones)
• fibrous papule of the face
• milia
• perioral dermatitis
• pseudofolliculitis of the beard
• rosacea
• seabather's eruption
• sporotrichosis
• syphilis
• syringoma
• trichilemmoma
• trichoepithelioma
• tuberous sclerosis

Management

• stop offending agent
• topical or oral antibiotics
• low-potency topical glucocorticoids

More general terms

• skin disease (dermatologic disorder, dermatopathy, dermatosis)
• eruption

More specific terms

• perioral dermatitis; periorificial dermatitis

Additional terms

• acne