thiamine (vitamin B1, Betalin)

^[1]^[2]^[3]^[4]^[5]^[6]

Introduction

Tradename: Betalin.

Indications

thiamine deficiency
beriberi
Wernicke's encephalopathy
prevention of Wernicke'e encephalopathy in patients with alcoholism brought to hospital with altered mental status
cataracts prophylaxis^[3]
septic shock^[4]

Dosage

RDA: male: 1.2-1.5 mg; female: 1.1 mg
- dietary intake for minimal risk of cognitive decline among older Chinese is 0.60-1.00 mg/day with inflection point at 0.68 mg/day^[5]
- association between thiamine intake & cognitive decline strongest in elderly with hypertension, obesity & non-smokers^[5]
wet berberi & myocardial failure: 10-20 mg IV TID
beriberi 10-20 mg IM TID for 2 weeks
prevention of Wernicke'e encephalopathy in alcoholics: 100 mg IV/IM
septic shock: 500 mg every 8 hours for 72 hours^[4]

Injection: 100 mg/mL (1 mL)

Tablets: 50 mg, 100 mg.

Adverse effects

uncommon (< 1%)
- allergic reactions & anaphylaxis
  - feelings of warmth
  - pruritus
  - paresthesias
  - rash
  - angioedema
  - nausea
  - cardiovascular collapse

Laboratory

More general terms

B vitamin

More specific terms

Additional terms

thiamine (vitamin B1) deficiency

Component of

References

↑ Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
↑ ^3.0 ^3.1 Jacques PF, Taylor A, Moeller S Long-term nutrient intake and 5-year change in nuclear lens opacification, Arch Ophthalmol. 2005 Apr;123(4):517-26. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15824226
↑ ^4.0 ^4.1 ^4.2 Woolum JA, Abner EL, Kelly A et al. Effect of thiamine administration on lactate clearance and mortality in patients with septic shock. Crit Care Med 2018 Jul 18; PMID: https://www.ncbi.nlm.nih.gov/pubmed/30028362 https://insights.ovid.com/crossref?an=00003246-900000000-96192
↑ ^5.0 ^5.1 ^5.2 Liu C, Meng Q, Wei Y et al J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, older Chinese individuals. Gen Psychiatr. 2024 Feb 20;37(1):e101311. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38390237 PMCID: PMC10882293 Free PMC Article
↑ Department of Veterans Affairs, VA National Formulary

Database

Kegg: http://www.genome.jp/dbget-bin/www_bget?
PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1130
PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6042

[ref1-1] Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998

[ref2-2] Kaiser Permanente Northern California Regional Drug Formulary, 1998

[ref3-3] 3.0 ^3.1 Jacques PF, Taylor A, Moeller S Long-term nutrient intake and 5-year change in nuclear lens opacification, Arch Ophthalmol. 2005 Apr;123(4):517-26. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15824226

[ref4-4] 4.0 ^4.1 ^4.2 Woolum JA, Abner EL, Kelly A et al. Effect of thiamine administration on lactate clearance and mortality in patients with septic shock. Crit Care Med 2018 Jul 18; PMID: https://www.ncbi.nlm.nih.gov/pubmed/30028362 https://insights.ovid.com/crossref?an=00003246-900000000-96192

[ref5-5] 5.0 ^5.1 ^5.2 Liu C, Meng Q, Wei Y et al J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, older Chinese individuals. Gen Psychiatr. 2024 Feb 20;37(1):e101311. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38390237 PMCID: PMC10882293 Free PMC Article

[ref6-6] Department of Veterans Affairs, VA National Formulary

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thiamine (vitamin B1, Betalin)

Contents

Introduction

Indications

Dosage

Adverse effects

Laboratory

More general terms

More specific terms

Additional terms

Component of

References

Database

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thiamine (vitamin B1, Betalin)

Introduction

Indications

Dosage

Adverse effects

Laboratory

More general terms

More specific terms

Additional terms

Component of

References

Database

Navigation menu

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