boceprevir (Victrelis)
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Indications
- chronic hepatitis C genotype 1 in combination with peginterferon & ribavirin
Dosage
Adverse effects
Drug interactions
- coadministration of boceprevir with ritonavir-boosted HIV protease inhibitors may reduce effectiveness, permitting HIV & HCV to proliferate; includes
- drug interaction(s) of fluticasone with HIV1 protease inhibitors
- drug interaction(s) of boceprevir in combination with ritonavir & Kaletra
- drug interaction(s) of boceprevir in combination with ritonavir & darunavir
- drug interaction(s) of boceprevir in combination with ritonavir & atazanavir
- drug interaction(s) of statins with antiviral protease inhibitors
- drug interaction(s) of antibiotics with warfarin
Mechanism of action
- protease inhibitor
- efficacy against HCV type-1
More general terms
References
- ↑ Poordad F et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011 Mar 31; 364:1195 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21449783
- ↑ Bacon BR et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011 Mar 31; 364:1207 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21449784
- ↑ Jensen DM. A new era of hepatitis C therapy begins. N Engl J Med 2011 Mar 31; 364:1272 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21449791
- ↑ FDA NEWS RELEASE: May 13, 2011 FDA approves Victrelis for Hepatitis C http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm255390.htm
- ↑ Prescriber's Letter 18(8): 2011 Victrelis (Boceprevir) and Incivek (Telaprevir) for Hepatitis C Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=270802&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 6.0 6.1 FDA MedWatch April 26, 2012 Victrelis (boceprevir) and Ritonavir-Boosted Human Immunodeficiency Virus (HIV) Protease Inhibitor Drugs: Drug Safety Communication - Drug Interactions http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm291144.htm