lopinavir/ritonavir (Kaletra)

^[1]^[2]^[3]^[4]^[5]^[6]

Introduction

treatment of HIV1/AIDS
- in combination with zidovudine & lamivudine, may be treatment of choice for pregnant women^[5]

must be protected from heat & moisture
- Norvir & Kaletra) can be dispensed in original container or USP equivalent container or can be stored outside of these containers for up to 2 weeks^[6]

diarrhea^[3]
also see lopinavir, ritonavir
premature babies may be at increased risk due to a diminished ability to eliminate propylene glycol leading to cardiac, renal & pulmonary problems^[4]

↑ Prescriber's Letter 7(10):57 2000
↑ Department of Veterans Affairs, VA National Formulary
↑ ^3.0 ^3.1 Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
↑ ^4.0 ^4.1 FDA MedWatch: 3/8/2011 Kaletra (lopinavir/ritonavir): Label Change - Serious Health Problems in Premature Babies
↑ ^5.0 ^5.1 Zuger A Use of Antiretroviral Drugs in Pregnancy. Physician's First Watch, April 22, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. 2014. AIDSinfo. Clinical Guidelines Portal. March 28, 2014. http://aidsinfo.nih.gov/Guidelines/HTML/3/perinatal-guidelines/0 (corresponding NGC guideline withdrawn March 2016)
↑ ^6.0 ^6.1 Prescriber's Letter 21(6): 2014 Oral Meds to Keep in Original Containers Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=300622&pb=PRL (subscription needed) http://www.prescribersletter.com