trafficking protein particle complex subunit 2 protein TRAPPC2P1; MBP-1-interacting protein 2A; MIP-2A (TRAPPC2P1, SEDLP1, TRAPPC219)

Function

• prevents transcriptional repression & induction of cell death by ENO1
• may play a role in vesicular transport from endoplasmic reticulum to Golgi
• interacts with PITX1, SF1, & TRAPPC3 (putative)
• can homodimerize (putative)
• part of the multisubunit TRAPP complex
• interacts with ENO1 & TRAPPC2L

Structure

• belongs to the TRAPP small subunits family, Sedlin subfamily

Compartment

• nucleus (putative). cytoplasm,
• perinuclear region
• endoplasmic reticulum, Golgi
• localized in perinuclear granular structures

Expression

• expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta & lymphocytes

Notes

• the gene encoding this protein appears to have arisen by retrotransposition of a cDNA from the X-linked locus TRAPPC2
• the site of integration of this retrotransposed cDNA ppears to lie within an intron of the ZNF547 gene, which provides a promoter & non-coding 5' exon
• TRAPPC2 & this protein are indistinguishable at protein level, & both proteins have been identified & functionally characterized

More general terms

• nuclear protein
• protein subunit

Additional terms

• trafficking protein particle complex subunit 2; Sedlin (TRAPPC2, SEDL)

Component of

• transport protein particle complex (TRAPP complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6399
• UniProt: http://www.uniprot.org/uniprot/P0DI82.html