pituitary homeobox 1; hindlimb-expressed homeobox protein backfoot; homeobox protein PITX1; paired-like homeodomain transcription factor 1 (PITX1, BFT, PTX1)

Function

• may play a role in the development of anterior structures, & in particular, the brain & facies & in specifying the identity or structure of hindlimb

Structure

• belongs to the paired homeobox family, Bicoid subfamily
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Pathology

• defects in PITX1 are a cause of congenital clubfoot

More general terms

• homeobox protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5307
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5307
• OMIM: https://mirror.omim.org/entry/119800
• OMIM: https://mirror.omim.org/entry/602149
• UniProt: http://www.uniprot.org/uniprot/P78337.html