telaprevir (Incivek)
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Indications
- chronic hepatitis C genotype 1
- may be used with peginterferon alfa & ribavirin[2] (Incivek combination treatment)
Dosage
- PO TID with food
- used in comination with peginterferon alfa & ribavirin for 1st 12 weeks of therapy[2]
Adverse effects
- rash, can be serious, may require stopping treatment[2]
- anemia
- nausea
- fatigue
- diarrhea
- pruritus
- rectal itching, rectal pain
Drug interactions
- serious skin reactions, some fatal, in combination with peginterferon alfa & ribavirin (Incivek combination treatment)[5]
- drug interaction(s) of fluticasone with HIV1 protease inhibitors
- drug interaction(s) of statins with antiviral protease inhibitors
- drug interaction(s) of antibiotics with warfarin
Mechanism of action
- protease inhibitor
- efficacy against HCV type-1
More general terms
References
- ↑ McHutchison JG et al Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009 Apr 30; 360:1827 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19403902
Hezode C et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009 Apr 30; 360:1839. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19403903
Hoofnagle JH. A step forward in therapy for hepatitis C. N Engl J Med 2009 Apr 30; 360:1899. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19403908 - ↑ 2.0 2.1 2.2 2.3 FDA NEWS RELEASE: May 23, 2011 FDA approves Incivek for hepatitis C http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm256299.htm
- ↑ Jacobson IM et al Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011 Jun 23; 364:2405 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21696307
Zeuzem S et al. Telaprevir for retreatment of HCV infection. N Engl J Med 2011 Jun 23; 364:2417 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21696308 - ↑ Prescriber's Letter 18(8): 2011 Victrelis (Boceprevir) and Incivek (Telaprevir) for Hepatitis C Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=270802&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 5.0 5.1 FDA MedWatch: Dec 19, 2012 Incivek (telaprevir) In Combination with Drugs Peginterferon Alfa and Ribavirin (Incivek combination treatment): Drug Safety Communication - Serious Skin Reactions. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm332860.htm