Human Leukocyte Antigen (HLA) testing

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Epidemiology

Pathology

Indications

Procedure

  • currently, the majority of HLA typing is done by molecular methods using commercially available kits
  • massively parallel sequencing
  • some laboratories can query single nucleotide variants associated with certain HLA alleles vs directly testing for the allele.

HLA typing for solid organ transplantation

Hematopoietic stem cell transplantation

Pharmacogenetics

* susceptibility to Stevens-Johnson syndrome & toxic epidermal necrolysis[6]

Disease associations

Notes

More general terms

More specific terms

References

  1. Prescriber's Letter 15(2): 2008 Labs for HLA (Human Leukocyte Antigen) Testing Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=240211&pb=PRL (subscription needed) http://www.prescribersletter.com
    Prescriber's Letter 16(1): 2009 Labs for HLA (Human Leukocyte Antigen) Testing Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=250109&pb=PRL (subscription needed) http://www.prescribersletter.com
  2. Khanna D et al 2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia Arthritis Care & Research, 64(10):1431-1446, October 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23024028 <Internet> http://onlinelibrary.wiley.com/doi/10.1002/acr.21772/abstract
  3. Labs that perform HLA testing American Red Cross, Philadelphia, PA (215) 451-4131
    Blood Systems Laboratories Histocompatibility Testing Services Tempe, AZ (866) 342-4275 http://www.bloodsystemslaboratories.org
    Calgary Laboratory Services-Tissue Typing Laboratory Calgary, Alberta (Canada) (403) 770-3652
    City of Hope National Medical Center Histocompatibility Laboratory, Duarte, CA (626) 256-8621
    The Histogenetics Laboratory, Inc., Ossining, NY (914) 762-0300 http://www.histogenetics.com
    Kashi Clinical Laboratories, Beaverton, OR (888) 732-4018
    Laboratory Corporation of America Holdings, Burlington, NC (800) 533-1037 http://www.labcorp.com
    METIC Immunogenetics Consultants, Inc., Los Angeles, CA (323) 441-1111 http://www.metic.com
    Quest Diagnostics Nichols Institute Chantilly, VA (800) 336-3718 http://www.questdiagnostics.com
    Specialty Laboratories, Valencia, CA (800) 421-4449 http://www.specialtylabs.com
    The Toronto Hospital Toronto, ON (Canada) (416) 340-4995
    Vancouver Acute, Laboratory Reception, Vancouver, BC (Canada) (604) 875-4111 http://www.vch.ca
  4. 4.0 4.1 Deprecated Reference
  5. 5.0 5.1 Moyer AM, Gandhi MJ. Human Leukocyte Antigen (HLA) Testing in Pharmacogenomics. Methods Mol Biol. 2022;2547:21-45. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36068459
  6. 6.0 6.1 Karnes JH, Rettie AE, Somogyi AA et al Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update. Clin Pharmacol Ther. 2021 Feb;109(2):302-309. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32779747 PMCID: PMC7831382 Free PMC article. Review.
  7. 7.0 7.1 Kamal S, Kerndt CC, Lappin SL Genetics, Histocompatibility Antigen National Library of Medicine, NCBI Bookshelf: StatPearls https://www.ncbi.nlm.nih.gov/books/NBK541023/
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 ARUP Laboratories HLA Testing https://arupconsult.com/content/hla-testing