demeclocycline (Declomycin)

Introduction

Tradename: Declomycin.

Indications

• treatment of syndrome of inappropriate antidiuretic hormone (SIADH)
• bacterial infections due to susceptible organisms
  • plague, tularemia, anthrax, brucellosis, actinomycosis, psittacosis, trachoma, typhus, rickettsialpox, borreliosis,
  • skin or soft tissue infection
  • acute otitis media
  • oral infection
    • gingivostomatitis
  • upper respiratory tract infection
    • pharyngitis, sinusitis
  • lower respiratory tract infection
    • pneumonia, bronchitis
  • intra-abdominal infection
    • gastrointestinal infection
      • enterocolitis
    • cholangitis
  • urogenital infection
    • syphilis, gonorrhea, chancroid, lymphogranuloma venereum, donovanosis, yaws
  • proctitis
  • eye disease
    • inclusion conjunctivitis

Contraindications

• do NOT administer to children < 9 years of age
• do NOT use in patients with hepatic cirrhosis

Caution: avoid prolonged exposure to sunlight

pregnancy category = d

safety in lactation = -

Dosage

• 150-300 mg PO BID
• maximum: 1200 mg/day

Tabs: 150 & 300 mg.

Antimicrobial activity

• Staphylococcus aureus
• Chlamydia
• Coxiella burnetii
• Neisseria gonorrhoeae
• Klebsiella
• Haemophilus influenzae
• Mycoplasma pneumoniae STAPHYLOCOCCUS_AUREUS

Adverse effects

• not common (1-10%)
  • photosensitivity
  • nausea/vomiting
  • diarrhea
• uncommon (< 1%)
  • pericarditis, increased intracranial pressure, pruritus, exfoliative dermatitis, diabetes insipidus, pigmentation of nails, anorexia, abdominal cramps, paresthesia, renal failure, azotemia, anaphylaxis

Drug interactions

(see tetracycline)

• drug interaction(s) anticonvulsants with anti-bacterial agents
• drug interaction(s) of antibiotics with warfarin

More general terms

• tetracycline (Achromycin, Sumycin, Bristacycline)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=31379
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2983
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311063
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5281009
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60978
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5281008