prazepam (Centrax)
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Introduction
Tradename: Centrax. DEA-controlled substance: class 4.
Dosage
Tabs: 5, 10, 20 mg.
Pharmacokinetics
- near complete 1st pass dealkylation in liver to active metabolite desmethyldiazepam
elimination via liver
elimination via kidney
1/2life = 36-200 hours
protein binding = 97 %
Adverse effects
- confusion
- ataxia
- excitement
- agitation
- transient hypotension
- vertigo
- drug fever
- dyspepsia
- leukopenia
- hepatotoxicity
- drug adverse effects of benzodiazepines
- drug adverse effects of psychotropic agents
- drug adverse effects of sedatives
Drug interactions
- carbamazepine may increase hepatic metabolism
- cimetidine, estrogens, disulfiram, erythromycin may inhibit hepatic metabolism
- drug interaction(s) of methadone in combination with benzodiazepines
- drug interaction(s) of benzodiazepines with antidepressants
- drug interaction(s) of benzodiazepines with thiazide diuretics
- drug interaction(s) of antipsycotics with benzodiazepines
- drug interaction(s) of antidepressants with benzodiazepines
- drug interaction(s) of beta-adrenergic receptor antagonists with benzodiazepines
- drug interaction(s) of beta-adrenergic receptor antagonists (except atenolol) with benzodiazepines
- drug interaction(s) of alcoholic beverage with benzodiazepines
- drug interaction(s) of benzodiazepine with opiates
Laboratory
More general terms
References
- ↑ 1.0 1.1 The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
- ↑ 2.0 2.1 Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 7
- ↑ Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelpha 1995