drug interaction(s) of benzodiazepine with opiates
Jump to navigation
Jump to search
Epidemiology
- concurrent use of benzodiazepines with opiates is on the rise[4]
Drug interactions
- concurrent benzodiazepine & opiate is associated with excess risk for overdose-related emergency room visits, hospital admissions, & death[1][4]
- benzodiazepines & opiates should not be used in combination[3]
- risk of overdose is increased with multiple prescribers[5]
Notes
- new concurrent prescriptions of opiates & benzodiazepines decreased by ~57% from 2016 to 2019.
More general terms
References
- ↑ 1.0 1.1 Park TW et al. Benzodiazepine prescribing patterns and deaths from drug overdose among US veterans receiving opioid analgesics: Case-cohort study. BMJ 2015; 350:h2698 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26063215 <Internet> http://www.bmj.com/content/350/bmj.h2698
- ↑ FDA Safety Alert. Aug 31, 2016 Opioid Pain or Cough Medicines Combined With Benzodiazepines: Drug Safety Communication - FDA Requiring Boxed Warning About Serious Risks and Death. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm518710.htm
FDA drug safety communication: Aug 31, 2016. FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines; requires its strongest warning. https://www.fda.gov/Drugs/DrugSafety/ucm518473.htm - ↑ 3.0 3.1 Anello J, Feinberg B, Heinegg J et al New Guidelines and Recommendations Guideline on oioid administration by Veterans Affaris and U.S. Department of Defense http://reference.medscape.com/features/slideshow/guidelines/2017/april
- ↑ 4.0 4.1 4.2 Sun EC, Dixit A, Humphreys K et al Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis. BMJ 2017;356:j760 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28292769 Free full text <Internet> http://www.bmj.com/content/356/bmj.j760
Karaca-Mandic P, Meara E, Morden NE. The growing problem of co-treatment with opioids and benzodiazepines. BMJ 2017;356:j1224 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28292825 Free full text <Internet> http://www.bmj.com/content/356/bmj.j1224 - ↑ 5.0 5.1 Chua KP, Brummett CM, Ng S et al Association Between Receipt of Overlapping Opioid and Benzodiazepine Prescriptions From Multiple Prescribers and Overdose Risk. JAMA Netw Open. 2021;4(8):e2120353 PMID: https://www.ncbi.nlm.nih.gov/pubmed/34374769 Free article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2782842
- ↑ Zhang K et al. Trends in concurrent opioid and benzodiazepine prescriptions in the United States, 2016 to 2019. Ann Intern Med 2022 Jun 7; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35667064 https://www.acpjournals.org/doi/10.7326/M21-4656