diatrizoate

Indications

• cerebral angiography
• urography
  • cystourethrography
• aortography
• arteriography
• splenoportography
• examination of the GI tract (powder)
• computerized tomography
• intravenous pyelography
• cholangiography
• hysterosalpingography
• venography

Contraindications

• hypersensitivity to diatrizoate or any of its components
• allergy to shellfish requires premedication (see contrast agent)

Adverse effects

• not common (1-10%)
• cardiac:
  • hypertension, hypotension, tachycardia, bradycardia, palpitations, chest pain, ventricular arrhythmias, cardiac arrest, pulmonary edema
• vascular:
  • venospasm, venous pain, thrombophlebitis, tissue necrosis at injection site,
• respiratory:
  • rhinitis, sneezing, shortness of breath, coughing, wheezing, laryngospasm, bronchospasm, laryngeal edema, nasal congestion
• skin:
  • urticaria, pruritus, rash, cellulitis, erythema,
• nervous system
  • seizures, dizziness, headache, pain, tremor,
• nausea/vomiting,
• acute renal failure
  • oliguria, transient proteinuria
• sensation of warmth

• drug adverse effects of contrast agents

Mechanism of action

• Oral contrast agent
• IV contrast agent: ionic, high osmolality
• contains organically bound iodine (290-370 mg/mL)

More general terms

• salt
• contrast agent

More specific terms

• diatrizoate sodium (Hypaque)

Component of

• diatrizoate meglumine/iodipamide (Sinografin)
• diatrizoate meglumine (Angiovist, Cystografin, Reno-M-60, Reno-M-Dip, Hypaque-Cysto, Hypaque Meglumine, Urovist Cysto, MD-76R, ME-Gastroview)
• diatrizoate meglumine/diatrizoate sodium (Gastrografin, Gastrovist, Renografin)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2140
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=12916
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5284541