ursodeoxycholic acid; ursodiol (Actigall)

From Aaushi
Jump to navigation Jump to search

Introduction

Tradename: Actigall.

Indications

* ursodiol inhibits expression of ACE2 (receptor for SARS-Cov2) in lung via binding to & inhibiting FXR[7]

Contraindications

  • delaying cholecystecomy in patients with symptomatic gallstones[5]

pregnancy category = b

safety in lactation = ?

Dosage

8-10 mg/kg/day PO divided BID/TID for 6-24 months

Tabs: 300 mg.

Pharmacokinetics

elimination via bile

Adverse effects

Drug interactions

Mechanism of action

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 329
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. 5.0 5.1 Venneman NG, Besselink MG, Keulemans YC, Vanberge-Henegouwen GP, Boermeester MA, Broeders IA, Go PM, van Erpecum KJ. Ursodeoxycholic acid exerts no beneficial effect in patients with symptomatic gallstones awaiting cholecystectomy. Hepatology. 2006 Jun;43(6):1276-83. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16729326
  6. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  7. 7.0 7.1 Brevini T, Maes M, Webb GJ et al FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature 2022. Dec 5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36470304 https://www.nature.com/articles/s41586-022-05594-0

Database