steroid biosynthesis

Biochemistry

• steroid biosynthesis 1
  • enzyme: multienzyme-complex
    • cholesterol desmolase, adrenodoxin, adrenodoxin reductase
  • substrate: cholesterol + NADPH + O2
  • product: pregnenolone + isocaproate + NADP
• steroid biosynthesis 2
  • enzyme: multienzyme-complex
    • steroid-17-hydroxylase, cytochrome-P450 reductase
  • substrate: pregnenolone + O2 + NADPH
  • product: 17-hydroxypregnenolone + NADP
• steroid biosynthesis 3
  • enzyme: multienzyme-complex
    • steroid-17-hydroxylase, cytochrome-P450 reductase
  • substrate: 17-hydroxypregnenolone + O2 + NADPH
  • product: ((dehydroepiandrosterone) (NADP)))
• steroid biosynthesis 4
  • enzyme: 3-hydroxysteroid dehydrogenase
  • substrate: pregnenolone + NADP
  • product: progesterone + NADPH
• steroid biosynthesis 5
  • enzyme: 3-hydroxysteroid dehydrogenase
  • substrate: 17-hydroxypregnenolone + NADP
  • product: 17-hydroxyprogesterone + NADPH
• steroid biosynthesis 6
  • enzyme: 3-hydroxysteroid dehydrogenase
  • substrate: dehydroepiandrosterone + NADP
  • product: androstenedione + NADPH
• steroid biosynthesis 7
  • enzyme: multienzyme-complex
    • steroid-17-hydroxylase, cytochrome-P450 reductase
  • substrate: ((progesterone) (O2) (NADPH))
  • product: ((17-hydroxyprogesterone) (NADP)))
• steroid biosynthesis 8
  • enzyme: ((multienzyme-complex
    • steroid-17-hydroxylase, cytochrome-P450 reductase
  • substrate: 17-hydroxyprogesterone + O2 + NADPH
  • product: androstenedione + NADP

More general terms

• biosynthetic pathway or anabolic pathway

More specific terms

• adrenal steroid biosynthesis
• gonadal steroid biosynthesis

Additional terms

• steroid

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?