adrenodoxin reductase (ferredoxin NADP reductase, FDXR)

Function

• serves as the 1st electron transfer protein in all the mitochondrial P450 systems, including
  • cholesterol side chain cleavage in all steroidogenic tissues
  • steroid 11-beta hydroxylation in the adrenal cortex
  • 25-OH-vitamin D3-24 hydroxylation in the kidney
  • sterol C-27 hydroxylation in the liver
• receives electrons from NADPH
• steroid metabolism; cholesterol metabolism
• interacts directly with FDX1 (putative)

2 reduced ferredoxin + NADP+ <--> 2 oxidized ferredoxin + NADPH

Cofactor: FAD

Structure

• monomer
• belongs to the ferredoxin--NADP reductase family

Compartment

mitochondria matrix

Alternative splicing

named isoforms=2

More general terms

• oxidoreductase
• flavoprotein
• mitochondrial membrane protein

Additional terms

• adrenodoxin, mitochondrial; adrenal ferredoxin; ferredoxin-1; hepatoredoxin (FDX1 ADX)
• steroid biosynthesis

Database

• UniProt: http://www.uniprot.org/uniprot/P22570.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2232
• OMIM: https://mirror.omim.org/entry/103270