adrenodoxin, mitochondrial; adrenal ferredoxin; ferredoxin-1; hepatoredoxin (FDX1 ADX)

Function

• adrenal ferredoxin
• role in the synthesis of thyroid hormones
• serves as an electron transport intermediate for mitochondrial forms of cyt P450
• transfers electrons from adrenodoxin reductase to the cytochrome P450 catalyzing cholesterol side chain cleavage

Cofactor:

• binds 1 2Fe-2S cluster: redox potential: E(0) is -448 mV

Structure

• belongs to the adrenodoxin/putidaredoxin family
• contains 1 2Fe-2S ferredoxin-type domain

Compartment

mitochondrial matrix

More general terms

• iron sulfur protein
• carrier protein (transporter)

Additional terms

• adrenodoxin reductase (ferredoxin NADP reductase, FDXR)
• steroid biosynthesis

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2230
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2230
• OMIM: https://mirror.omim.org/entry/103260
• UniProt: http://www.uniprot.org/uniprot/P10109.html