cytochrome P450 11A1 (CYP11A1, cholesterol 20,22 desmolase, cytochrome P450 SCC, CYP11A1)
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Function
- catalyzes all three steps in cleavage of cholesterol to pregnenolone & isocaproic acid
- lipid metabolism; C21-steroid hormone metabolism
Structure
belongs to the cytochrome P450 family
Compartment
Expression
induced by 8-bromo cyclic AMP
Pathology
- defects in CYP11A1 are a cause of
- inhibition of CYP11A1 may improve survival in castration-resistant prostate cancer (investigational)[3]
More general terms
Additional terms
References
- ↑ OMIM [201710 118485]
- ↑ UniProt http://www.uniprot.org/uniprot/P05108.html
- ↑ 3.0 3.1 Fizazi K et al. Targeted inhibition of CYP11A1 in castration-resistant prostate cancer. NEJM Evid 2024 Jan; 3:EVIDoa2300171. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38320513 PMCID: PMC10852404 Free PMC article. https://evidence.nejm.org/doi/10.1056/EVIDoa2300171
Database
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1583
- UniProt: http://www.uniprot.org/uniprot/P05108.html
- OMIM: https://mirror.omim.org/entry/118485
- OMIM: https://mirror.omim.org/entry/184700
- OMIM: https://mirror.omim.org/entry/201710
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1583