botulism

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Introduction

An acute, potentially fatal disease resulting from ingestion of Clostridium botulinum or Clostridium botulinum toxin.

Etiology

Epidemiology

  • 9 cases of wound botulism associated with injecting heroin from Sept 2017 to May 2018 in San Diego county []

Pathology

Clinical manifestations

Laboratory

Differential diagnosis

Management

More general terms

Additional terms

References

  1. DeGowin & DeGowin's Diagnostic Examination, 6th edition, RL DeGowin (ed), McGraw Hill, NY 1994, pg 869-70
  2. 2.0 2.1 Arnon SS et al, Human botulism immune globulin for the treatment of infant botulism. N Engl J Med 2006, 354:462 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16452558
  3. 3.0 3.1 3.2 3.3 Medical Knowledge Self Assessment Program (MKSAP) 14, 15, 16, 17, 18, 19. American College of Physicians, Philadelphia 2006, 2009, 2012, 2015, 2018, 2021.
  4. Cherington M. Botulism: update and review. Semin Neurol. 2004 Jun;24(2):155-63. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15257512
  5. David WS, Temin ES, Kraeft JJ, Hooper DC. Case records of the Massachusetts General Hospital. Case 3-2015. A 60-year-old woman with abdominal pain, dyspnea, and diplopia. N Engl J Med. 2015 Jan 22;372(4):364-72 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25607430 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMcpc1410936
  6. Zhang JC, Sun L, Nie QH. Botulism, where are we now? Clin Toxicol (Phila). 2010 Nov;48(9):867-79. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21171845
  7. Peak CM, Rosen H, Kamali A, et al. Wound Botulism Outbreak Among Persons Who Use Black Tar Heroin - San Diego County, California, 2017-2018. MMWR Morb Mortal Wkly Rep 2019;67:1415-1418. https://www.cdc.gov/mmwr/volumes/67/wr/mm675152a3.htm
  8. CDC's botulism treatment program http://www.bt.cdc.gov/agent/botulism

Patient information

botulism patient information