Hodgkin's disease, lymphocyte predominant type
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Introduction
Clinical features: Occurs at all ages, adults > children, males > females. Involves peripheral lymph nodes with sparing of mediastinum. Usually localized at diagnosis. Long survival rates for localized cases. Late relapses more common than other types of Hodgkins. May be associated with large B-cell lymphoma.
Pathology
predominantly lymphocytes with or without histiocytes, plasma cells, eosinophils and neutrophils rare. nodular pattern with or without diffuse areas. atypical cells with lobulated vesicular nuclei, designated L&H (lymphocyte and/or histiocyte) or popcorn cells. usually no diagnostic Reed-Sternberg cells.
Immunophenotype
atypical cells
Genetics
More general terms
References
- ↑ Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994 Sep 1;84(5):1361-92. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8068936