glucocorticoid suppressible hyperaldosteronism (GSH); glucocorticoid remediable aldosteronism (GRA)
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Pathology
- regulation of aldosterone secretion by ACTH
Genetics
- autosomal dominant
- chimeric gene duplication:
- 11-beta-hydroxylase promoter fused to aldosterone synthase coding sequence; therefore aldosterone synthase production becomes regulated by ACTH
Clinical manifestations
Laboratory
- serum K+: hypokalemia may or may not be present
- serum bicarbonate: metabolic acidosis
- plasma renin: low
- plasma aldosterone: moderately high
Management
- aldosterone antagonists, potassium-sparing diuretics
- glucocorticoid
- dexamethasone has less mineralocorticoid activity than other glucocorticois[2]
More general terms
References
- ↑ Harrison's Principles of Internal Medicine; McGraw-Hill, 13th ed. 1994; p.1967.
- ↑ Jump up to: 2.0 2.1 Medical Knowledge Self Assessment Program (MKSAP) 15, 17, 18. American College of Physicians, Philadelphia 2009, 2015, 2018.