growth hormone-releasing hormone; somatotropin-releasing hormone,; somatocrinin; somatoliberin (GHRH)

Function

• induces growth hormone release from pitituary somatotrophs
• synergistic with endogenous GHRP in stimulating GH release from the pituitary

Compartment

• secreted
• released from the hypothalamus into the portal circulation

Expression

• may be secreted in a pulsatile manner &/or in alternation with somatostatin, giving rise to the pulsatile secretion of growth hormone from the anterior pituitary

Pharmacology

see recombinant growth hormone-releasing hormone

More general terms

• pituitary hormone-releasing hormone; hypothalamic hormone
• secretin family peptide

More specific terms

• recombinant growth hormone-releasing hormone
• sermorelin (Geref)

Additional terms

• appetite-regulating hormone; growth hormone secretagogue; growth hormone-releasing peptide; motilin-related peptide; M46 protein; contains: ghrelin-27, ghrelin-28, ghrelin, obestatin (GHRL, MTLRP, UNQ524/PRO1066)
• growth hormone-releasing hormone receptor; GHRH receptor; GRF receptor; GRFR (GHRHR)
• insulin-like growth factor-1; mechano growth factor; MGF; somatomedin-C (IGF1, IBP1)
• somatotropin; growth hormone; somatropin (GH)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2691
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2691
• OMIM: https://mirror.omim.org/entry/139190
• UniProt: http://www.uniprot.org/uniprot/P01286.html