growth hormone secretagogue receptor type 1; GHS-R; GH-releasing peptide receptor; GHRP; ghrelin receptor (GHSR)

Function

• receptor for ghrelin
• coupled to G-alpha-11 proteins
• stimulates growth hormone secretion
• also binds other growth hormone releasing peptides (GHRP) (Met-enkephalin & GHRP-6) as well as non-peptide, LMW secretagogues (L-692,429, MK-0677, adenosine)

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Alternative splicing

named isoforms=2; 1A,1B

Expression

pituitary & hypothalamus

Pathology

• defects in GHSR may be a cause of short stature

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2693
• OMIM: https://mirror.omim.org/entry/601898
• OMIM: https://mirror.omim.org/entry/604271
• UniProt: http://www.uniprot.org/uniprot/Q92847.html