short stature

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Etiology

Epidemiology

  • 0.1-2.5% of the population

Genetics

  • associated with defects in GHR
  • associated with defects in GHSR
  • associated with defects in SHOX[3]

Clinical manifestations

  • subnormal rate of growth
    • height below the third percentile for chronological age
  • behavior & intelligence is normal

Management

  • none indicated
  • growth hormone increases size, but no evidence it improves outcomes

More general terms

References

  1. Journal Watch 24(7):57, 2004
    Wheeler PG et al Arch Pediatr Adolesc Med 158:246, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14993082
  2. OMIM https://mirror.omim.org/entry/604271
  3. 3.0 3.1 OMIM https://mirror.omim.org/entry/300582
  4. Allen DB and Cuttler L. Clinical practice. Short stature in childhood--challenges and choices. N Engl J Med 2013 Mar 28; 368:1220 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23534561 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMcp1213178

Database