growth hormone-releasing hormone receptor; GHRH receptor; GRF receptor; GRFR (GHRHR)

Function

• receptor for GRF
• coupled to G proteins which activate adenylyl cyclase
• stimulates somatotroph cell growth, growth hormone gene transcription & growth hormone secretion

Structure

belongs to the G-protein coupled receptor 2 family

Compartment

cell membrane

Expression

pituitary gland

Pathology

• defects in GHRHR are a cause of isolated growth hormone deficiency type 1B

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2692
• OMIM: https://mirror.omim.org/entry/139191
• OMIM: https://mirror.omim.org/entry/262400
• UniProt: http://www.uniprot.org/uniprot/Q02643.html