recombinant growth hormone-releasing hormone

Indications

• growth hormone deficiency in the elderly
• may have beneficial effect on some cognitive measures in both normal elderly and those with amnestic MCI (mild cognitive impairment)

Dosage

14 ug/kg SC QHS (long-acting GHRH)

Monitor

IGF-1

Adverse effects

• increased prolactin
• increased ACTH

Mechanism of action

• induces growth hormone release from pitituary somatotrophs
• less effective than growth hormone
• probably safe
• may have beneficial effect on cognitive function

Notes

• cost 2012: $50/injection

More general terms

• growth hormone-releasing hormone
• recombinant protein; chimer
• endocrine agent

Additional terms

• appetite-regulating hormone; growth hormone secretagogue; growth hormone-releasing peptide; motilin-related peptide; M46 protein; contains: ghrelin-27, ghrelin-28, ghrelin, obestatin (GHRL, MTLRP, UNQ524/PRO1066)
• growth hormone-releasing hormone receptor; GHRH receptor; GRF receptor; GRFR (GHRHR)
• insulin-like growth factor-1; mechano growth factor; MGF; somatomedin-C (IGF1, IBP1)
• somatotropin; growth hormone; somatropin (GH)