cAMP responsive element-binding protein 3-like protein 4 (androgen-induced basic leucine zipper protein, AIbZIP, cyclic AMP-responsive element-binding protein 4, attaching to CRE-like 1, ATCE1, transcript induced in spermiogenesis protein 40, Tisp40, hJAL, CREB3L4, AIBZIP, CREB4, JAL)
Jump to navigation
Jump to search
Function
- transcriptional activator
- may play a role in the unfolded protein response
- binds to the UPR element (UPRE) but not to CRE element
- preferentially binds to DNA consensus sequence 5'-T[GT]ACGT[GA][GT]-3'
- has transcriptional activation activity from UPRE
- binds to NF-kappa-B site & has transcriptional activation activity from NF-kappa-B-containing regulatory elements
- binds DNA as a dimer
- controlled by regulated intramembrane proteolysis
- following ER stress, a fragment containing the cytoplasmic transcription factor domain is released by proteolysis
Structure
- N-glycosylated in the C-terminal region
- belongs to the bZIP family. ATF subfamily.
- contains 1 bZIP domain
Compartment
- endoplasmic reticulum membrane
- processed form: nucleus
- under ER stress, cleaved N-terminal cytoplasmic domain translocates into nucleus
- may also be located in Golgi apparatus
Expression
- expressed in prostate
- expressed in prostatic luminal epithelial cells
- also expressed in brain, pancreas, skeletal muscle > small intestine, testis, leukocyte & thymus
- induced by androgens
Pathology
- expressed in breast & prostate cancer cell lines
- expression is significantly more abundant in prostate cancer than in benign prostatic hyperplasia
More general terms
- basic leucine zipper (bZIP) family protein
- DNA-binding protein
- transcription factor (TF)
- glycoprotein
- membrane protein