ankyrin repeat domain-containing protein 1 (cardiac ankyrin repeat protein, cytokine-inducible nuclear protein, C-193)

Function

• role in endothelial cell activation (putative)
• nuclear transcription factor that negatively regulates expression of cardiac genes (putative)
• induction appears correlated with apoptotic cell death in hepatoma cells
• interacts with YBX1, TTN/titin

Structure

contains 5 ANK repeats

Compartment

nucleus

Expression

• mainly expressed in activated vascular endothelial cells
• induced by TNF, IL1A & parthenolide

Pathology

expressed in hepatoma cells

More general terms

• transcription factor (TF)
• ankyrin repeat domain protein (ANKRD)

Database

• UniProt: http://www.uniprot.org/uniprot/Q15327.html