zinc finger protein 40; Human immunodeficiency virus type I enhancer-binding protein 1; HIV-EP1; major histocompatibility complex-binding protein 1; MBP-1; positive regulatory domain II-binding factor 1; PRDII-BF1 (HIVEP1, ZNF40)

Function

• specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters including those of SV40, CMV, & HIV1
• related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, & interferon-beta genes
• may act in T-cell activation

Structure

• contains two sets of 2 Zn+2-fingers, which are widely separated & recognize the same DNA sequence
• there is a fifth Zn+2-finger in-between
• contains 5 C2H2-type Zn+2 fingers

Compartment

nucleus

Expression

induced by mitogens & phorbol ester

More general terms

• DNA-binding protein
• transcription factor (TF)
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3096
• OMIM: https://mirror.omim.org/entry/194540
• UniProt: http://www.uniprot.org/uniprot/P15822.html