transient receptor potential cation channel subfamily V member 4 (TrpV4, vanilloid receptor-like 2, VRL-2, osm-9-like TRP channel 4, OTRPC4, vanilloid receptor-related osmotically-activated channel, VR-OAC, transient receptor potential protein 12, TRP12, VRL2, VROAC)

Function

• non-selective Ca+2 channel
• involved in osmotic sensitivity & mechanosensitivity
• activation by hypotonicity within the physiological range exhibits an outward rectification
• activated by low pH, citrate, phorbol esters
• increased intracellular Ca+2 potentiates currents
• channel activity regulated by calmodulin
• interacts with calmodulin, Map7, Src family Tyr kinases LYN, SRC, FYN, HCK, LCK, YES

Compartment

membrane

Alternative splicing

named isoforms=3

More general terms

• transient receptor potential cation channel subfamily V (TRPV)
• Ca+2 channel
• transmembrane 6 protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/605427
• UniProt: http://www.uniprot.org/uniprot/Q9HBA0.html