C-type lectin domain family 11 member A; C-type lectin superfamily member 3; lymphocyte secreted C-type lectin; stem cell growth factor; p47 (CLEC11A, CLECSF3, LSLCL, SCGF)

Function

• stimulates proliferation & differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes & macrophages
• acts synergistically with other cytokines, including IL-3, GCSF, GMCSF & FLT3 ligand
• suppresses SCF-stimulated erythrocyte proliferation

Structure

• O-glycosylated
• probably sulfated on the O-glycans
• contains 1 C-type lectin domain

Compartment

cytoplasm. secreted

Expression

• expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, perichondrium & periosteum
• lower levels of expression in spleen, thymus, appendix & fetal liver
• in the bone marrow, expression is limited to immature neutrophils
• not expressed in circulating mature neutrophils

More general terms

• C-type lectin superfamily

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6320
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6320
• OMIM: https://mirror.omim.org/entry/604713
• UniProt: http://www.uniprot.org/uniprot/Q9Y240.html