bone morphogenetic protein 10; BMP-10 (BMP10)

Function

• required for maintaining proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP & maintaining the required expression levels of cardiogenic factors such as MEF2C & NKX2-5
• acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 & BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 & SMAD8
• inhibits endothelial cell migration & growth

Structure

• homodimer; disulfide-linked (putative)
• belongs to the TGF-beta family

Compartment

secreted (putative)

More general terms

• bone morphogenetic protein (BMP)
• TGF-beta family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27302
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27302
• OMIM: https://mirror.omim.org/entry/608748
• UniProt: http://www.uniprot.org/uniprot/O95393.html