cyclin-dependent kinase inhibitor 1C; cyclin-dependent kinase inhibitor p57; p57KIP2 (CDKN1C KIP2)

Function

• potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, & cyclin A-CDK2) &, to lesser extent, of the mitotic cyclin B-CDC2
• negative regulator of cell proliferation
• may play a role in maintenance of the non-proliferative state throughout life

Structure

belongs to the CDI family

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2; long, short

Expression

• expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas & testis
• high levels are seen in the placenta
• low levels are seen in the liver

Pathology

• defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome
• defects in CDKN1C are involved in tumor formation

More general terms

• nuclear protein
• cyclin-dependent kinase inhibitor (CDKI, CDKN)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1028
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1028
• OMIM: https://mirror.omim.org/entry/130650
• OMIM: https://mirror.omim.org/entry/600856
• UniProt: http://www.uniprot.org/uniprot/P49918.html