interleukin-28B; IL-28B; cytokine Zcyto22; interferon lambda-3; IFN-lambda-3; interleukin-28C; IL-28C (IL28B, IFNL3, IL28C, ZCYTO22)

Function

• cytokine with immunomodulatory activity
• antiviral immunity
• up-regulates MHC class I antigen expression
• ligand for the heterodimeric class II cytokine receptor IL10RB/IL28RA
• signals through the Jak-STAT pathway.

Compartment

secreted

Expression

induction by viral infections or dsRNA

Pharmacology

• IL28B variation rs12979860 predicts response to PEG-interferon-alpha

More general terms

• interleukin

Additional terms

• interferon lambda-4; IFN-lambda-4 (IFNL4)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=282617
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:282617
• OMIM: https://mirror.omim.org/entry/607402
• UniProt: http://www.uniprot.org/uniprot/Q8IZI9.html