tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; vascular endothelial cell growth inhibitor (TNFSF15, TL1, VEGI)

Function

• receptor for TNFRSF25 & TNFRSF6B. mediates activation of NF-kappa-B
• inhibits vascular endothelial growth & angiogenesis (in vitro)
• promotes activation of caspases & apoptosis

Structure

• homotrimer
• belongs to the tumor necrosis factor family

Compartment

• membrane; single-pass type 2 membrane protein (probable)
• secreted

Alternative splicing

named isoforms=3

Expression

• specifically expressed in endothelial cells
• detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine & colon
• up-regulated by IL1A/interleukin-1 alpha & TNF

More general terms

• tumor necrosis factor (TNF) family protein
• cell surface receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9966
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9966
• OMIM: https://mirror.omim.org/entry/604052
• UniProt: http://www.uniprot.org/uniprot/O95150.html