tumor necrosis factor receptor superfamily member 25; WSL-1 protein; apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; Death domain receptor 3; WSL protein; apoptosis-inducing receptor AIR; apo-3; lymphocyte-associated receptor of death; LARD (TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, UNQ455/PRO779)

Function

• receptor for TNFSF12/APO3L/TWEAK
• interacts directly with the adapter TRADD
• mediates activation of NF-kappa-B & induces apoptosis
• may play a role in regulating lymphocyte homeostasis
• interacts strongly via the death domains with TNFRSF1 & TRADD to activate at least 2 distinct signaling cascades, apoptosis & NF-kappa-B signaling.
• interacts with BAG4

Structure

• homodimer
• glycosylated (probable)
• contains 1 death domain
• contains 4 TNFR-Cys repeats

Compartment

• isoforms 1,2,9,11: cell membrane
• isoforms 3,4,5,6,7,8,10,12: secreted

Alternative splicing

named isoforms=12

Expression

• abundantly expressed in thymocytes & lymphocytes
• detected in lymphocyte-rich tissues incuding: thymus, colon, intestine, & spleen
• also found in the prostate

Notes

• some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• tumor necrosis factor [TNF] receptor family
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8718
• OMIM: https://mirror.omim.org/entry/603366
• UniProt: http://www.uniprot.org/uniprot/Q93038.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8718