CD101; immunoglobulin superfamily member 2; Glu-Trp-Ile EWI motif-containing protein 101; EWI-101; cell surface glycoprotein V7 (CD101, EWI101, IGSF2, V7)

Function

• role as inhibitor of T-cells proliferation induced by CD3
• inhibits expression of IL2RA on activated T-cells & secretion of IL2
• inhibits tyrosine kinases required for IL2 production & cellular proliferation
• inhibits phospholipase C-gamma-1/PLCG1 phosphorylation & subsequent CD3-induced changes in intracellular free Ca+2
• prevents nuclear translocation of NFAT to nucleus
• role in inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells

Structure

• N-Glycosylated
• contains 7 Ig-like C2-type domains (immunoglobulin-like)

Compartment

membrane

Expression

• expressed in lung, thymus, small intestine
• expressed in cutaneous dendritic cells, activated T-cells, monocytes, granulocytes, epithelial cells with dendritic morphology

Pathology

• expressed in some leukemic cells, CD4(+) CD56(+) blastic tumor cells from patients with Langerhans cell histiocytosis
• marker of CD4(+) CD56(+) leukemic tumor cells (putative)

More general terms

• CD antigen
• immunoglobulin superfamily protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9398
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9398
• OMIM: https://mirror.omim.org/entry/604516
• UniProt: http://www.uniprot.org/uniprot/Q93033.html