solute carrier family 22 member 6 (organic cation transporter 1, hOAT1, renal organic anion transporter 1, hROAT1, PAH transporter, hPAHT, SLC22A6, OAT1, PAHT)

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Function

role in the renal elimination of endogenous & exogenous organic anions
mediates the Na+-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (putative)
mediates the Na+-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) & 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) & edaravone sulfate.
p-aminohippurate uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate & okadaic acid (putative), benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), Ca+2ophore A23187, benzylpenicillin, indomethacin, bumetanide, losartan, probenecid, phenol red, urate, & alpha-ketoglutarate

glycosylated
glycosylation at Asn-113 may occur at a secondary level
glycosylation is necessary for proper targeting of the transporter to the plasma membrane
multiple Cys are necessary for proper targeting to the plasma membrane (putative)
belongs to the major facilitator superfamily, organic cation transporter family