solute carrier family 22 member 7 (organic anion transporter 2, hOAT2, novel liver transporter, SLC22A7, NLT, OAT2)

Function

• mediates Na+-independent multispecific organic anion transport
• transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, & alpha- ketoglutarate

Kinetic parameters:

• KM=713 nM for prostaglandin E2
• KM=440 uM for tetracycline

Structure

• belongs to the major facilitator superfamily. Organic cation transporter family

Compartment

• basolateral cell membrane
• apical side of the renal tubule

Alternative splicing

named isoforms=4

Expression

expressed in liver & kidney

More general terms

• membrane protein
• solute carrier family 22 (SLC22, SLC22A)

Database

• OMIM: https://mirror.omim.org/entry/604995
• UniProt: http://www.uniprot.org/uniprot/Q9Y694.html