general receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein, GRASP)

Function

• role in intracellular trafficking
• role in macromolecular organization of group 1 metabotropic glutamate receptors at synapses
• interacts with PSCD3, GRM2, GRM3, GRM5
• component of heteromer composed of GRASP, PSCD2 & at least one GRM1

Structure

• contains 1 PDZ domain (DHR domain)

Compartment

• cytoplasm, perinuclear region
• cell membrane, cytoplasmic side
• cell junction, synapse, postsynaptic cell membrane
• localized at postsynaptic membranes

Alternative splicing

named isoforms=2

More general terms

• scaffold protein
• phosphoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z6J2.html