Metabotropic glutamate receptor 3; mGluR3 (GRM3, GPRC1C, MGLUR3)
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Function
- receptor for N-acetylaspartylglutamate (NAAG)
- receptor for glutamate ?
- activity is mediated by a Gi-protein
- interacts with GRASP (putative)
Structure
belongs to the G-protein coupled receptor 3 family
Compartment
Pathology
- loss of receptors or decline in function within the dorsolateral prefrontal cortex (DLPFC) may play a role in schizophrenia[2]
Pharmacology
- experimental drug used to treat schizophrenia
Pharmacokinetics
- LY2140023, an investigational drug used for treatment of schizophrenia, is prodrug hydrolyzed to LY404039, a metabotropic glutamate receptor agonist specific for mGluR2 & mGluR3[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q14832.html
- ↑ 2.0 2.1 2.2 Ghose S et al. Differential expression of metabotropic glutamate receptors 2 and 3 in schizophrenia: A mechanism for antipsychotic drug action? Am J Psychiatry 2009 Jun 1; [e-pub ahead of print]. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19487395 <Internet> http://dx.doi.org/10.1176/appi.ajp.2009.08091445