NFAT activation molecule 1; calcineurin/NFAT-activating ITAM-containing protein; NFAT-activating protein with ITAM motif 1 (NFAM1, CNAIP)

Function

• may function in immune system as a receptor that activates downstream cytokine genes via the calcineurin/NFAT-signaling pathway
• activates transcription of IL-13 & TNF-alpha genes
• may be involved in regulation of B-cell, but not T-cell, development
• overexpression activates downstream effectors without ligand binding or antibody cross-linking
• interacts with ZAP70 & SYK
• no direct interaction with the B-cell antigen receptor (BCR) (putative)

Structure

• N-glycosylated
• the ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions
• the phosphorylated ITAM domain binds ZAP70 & SYK
• contains 1 Ig-like V-type domain
• contains 1 ITAM domain

Compartment

• cell membrane; single-pass type 1 membrane protein (putative)
• partially recruited to lipid rafts upon BCR stimulation (putative)

Expression

• highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines & lymphocytes
• also expressed in spleen B & T cells, & lung
• expressed at low level in non-immune tissue

More general terms

• membrane protein
• glycoprotein
• phosphoprotein

Additional terms

• calcineurin; serine/threonine protein phosphatase 3 (formerly PP2B)
• immunoreceptor tyrosine-based activator motif (ITAM)
• nuclear factor of activated T-cells (NFATC transcription complex, NFAT)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=150372
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:150372
• OMIM: https://mirror.omim.org/entry/608740
• UniProt: http://www.uniprot.org/uniprot/Q8NET5.html