Interleukin-31 receptor A (IL-31RA, cytokine receptor-like 3, Gp130-like monocyte receptor, GLM-R, HGLM-R, Gp130-like receptor, IL31RA, CRL3, GPL, UNQ6368/PRO21073/PRO21384)

Function

• associates with OSMR to form the interleukin-31 receptor which activates STAT3 & to a lower extent STAT1 & STAT5
• may function in skin immunity
• heterodimer with OSMR
• interacts with JAK1 & STAT3

Structure

• N-glycosylated
• belongs to the type I cytokine receptor family, type 2 subfamily
• contains 5 fibronectin F3 modules

Compartment

cell membrane

Alternative splicing

named isoforms=12

Expression

• expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea & skin
• detected in all of the myelomonocytic lineage
• expressed in CD14- & CD56-positive blood cells & by macrophages (at protein level)
• up-regulated by IFNG & lipopolysaccharides

Pathology

• up-regulated in lesional keratinocytes of patients with atopic dermatitis

More general terms

• membrane protein
• protein subunit

Component of

• interleukin-31 receptor (IL13 receptor)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1333
• OMIM: https://mirror.omim.org/entry/609510
• UniProt: http://www.uniprot.org/uniprot/Q8NI17.html