bone marrow stromal antigen 2; BST-2; tetherin; HM1.24 antigen; CD317 (BST2)

Function

• may be involved in the sorting of secreted proteins
• may be involved in pre-B-cell growth
• antiretroviral defense protein, that blocks release of retrovirus from the cell surface
• depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation
• may play a role in B-cell activation in rheumatoid arthritis

Structure

• homodimer (probable)

Compartment

• Golgi, trans-Golgi network
• cell membrane; single-pass type 2 membrane protein
• cell membrane; lipid-anchor, GPI-anchor

Expression

• predominantly expressed in liver, lung, heart & placenta
• lower levels in pancreas, kidney, skeletal muscle & brain
• overexpressed in multiple myeloma cells
• highly expressed during B-cell development, from pro B-cell precursors to plasma cells
• highy expressed on T-cells, monocytes, NK cells & dendritic cells (at protein level)
• during B-cell activation (at protein level), or by interferon-alpha as part of entiviral state cellular program

More general terms

• glypiated protein
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=684
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:684
• OMIM: https://mirror.omim.org/entry/600534
• UniProt: http://www.uniprot.org/uniprot/Q10589.html