complement C1r subcomponent-like protein (C1r-like protein, C1r-LP, C1r-like serine protease analog protein, CLSPa, C1RL, C1RL1, C1RLP, CLSPA)
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Function
- mediates proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum
- does not associate with the C1 complex
- does not cleave the proform of complement C1s[2]
Structure
- belongs to the peptidase S1 family
- contains 1 CUB domain
- contains 1 peptidase S1 domain
Compartment
Expression
- expressed in placenta, liver, kidney, pancreas > lung, spleen, prostate, ovary, colon, peripheral blood leukacytes > heart, skeletal muscle, thymus, testis, & small intestine
- expressed mainly in liver & in serum (at protein level)
- up-regulated in monocytes & dendritic cells undergoing maturation or activation
Pathology
- expressed in PC-3 (prostate adenocarcinoma) & SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo & HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U251 (glioma) or A549 (lung carcinoma) cells
- widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 & NB4 (promyelocytic leukemia), & KG-1 (acute myelogenous leukemia) cells
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9NZP8.html
- ↑ 2.0 2.1 Wicher KB, Fries E. Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein. Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14390-5. Epub 2004 Sep 22. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15385675