signaling threshold-regulating transmembrane adapter 1 (SHP2-interacting transmembrane adapter protein, gp30/40, SIT1, SIT)

Function

• negatively regulates TCR-mediated signaling in T-cells
• positive selection of T-cells
• phosphorylated on TYR by LCK, FYN or ZAP70 upon TCR activation
• when phosphorylated, interacts with PTPN11/SHP2, GRB2, CSK

Structure

homodimer, disulfide-linked

Compartment

cell membrane

Expression

• expressed in T-cells & B-cells
• expressed in plasma cells but not in germinal center B-cells

Pathology

• expressed in T-cell lymphoma, B-cell lymphoma

More general terms

• phosphoprotein
• oligomerizing protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/604964
• UniProt: http://www.uniprot.org/uniprot/Q9Y3P8.html